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Single-use, sterile infusion system for the preparation and administration of different cytotoxic drugs via one single closed line-system by gravity or pressure with bottles and bags according to the SPC (Summary of product characteristics) of the drugs/solutions. Cyto-Set® is used for the application of cytotoxic agents in a closed system. The Cyto-Set® system reduces the probability of contamination of person and environment when preparing and applying cytotoxic drugs ensured by its technical components forming a closed system and the resulting workflow. Cyto-Set® Mix Connection system for Cyto-Set® gravity infusion- and Infusomat® Space sets. The Cyto-Set® Mix allows to connect a normal infusion container with a solution dedicated for cytotoxic drugs (NaCl 0,9% or Glucose 5%) to vent the line. The drug is put in the container via a needle-free injection valve. So the line of the Cyto-Set® Mix leading to Cyto-Set® Infusion, Cyto-Set® Infusomat® Space or Cyto-Set® Infusomat® plus is free of cytotoxic drugs.